Güncelleme Tarihi: 7 Aralık 2023


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What is Mesotherapy?

It is the process of injecting various drug solutions into the skin, cartilage, muscle, or fat tissues that develop from the layer called "mesoderm". In mesotherapy, the principle of injecting solutions only into the diseased area with the least dose possible is essential. The substances to be injected differ according to the mechanism of the problem.

History of Mesotherapy

Mesotherapy technique was first used by the French physician Dr. Pistor in 1952 in the treatment of vascular and lymphatic disorders. In 1987, French Medical Academy officially recognized Mesotherapy as a specialty of medicine. It is considered as part of medical studies in Europe. It has been recognized and started to be implemented in the USA more recently. Today, it is widely applied in many countries all over the world.

How is Mesotherapy Applied?

The mesotherapy needles used for cosmetic purposes is very thin (with a length of 4 or 6 mm). These needles are specially produced for painless injections. In very sensitive people with low pain threshold, special creams or sprays can be used to prevent pain or ice application can be done before the procedure.

Duration of the procedure is generally 15-20 minutes.

Injections can be administered manually or with the help of a mechanical or electronic device. All three techniques have their own advantages.

In mesotherapy, 8 - 500 injections are administered depending on the condition and size of the area to be treated. Injection techniques vary depending on the purpose. Applications with a depth of 0.5-1 mm, 1-2 mm, 2-5 mm are the most commonly used techniques in mesotherapy for cosmetic purposes.

For Which Medical Purposes is Mesotherapy Applied?

Apart from cosmetic purposes, mesotherapy technique is also used in many areas of medicine, such as:

  • Arthrosis, arthritis, rheumatism, sports injuries
  • Allergic diseases such as asthma, allergic rhinitis
  • Peripheral vascular diseases, lymphedema, varicose veins, venous ulcer
  • Neurological diseases, diseases with spasm, migraine

For Which Cosmetic Purposes is Mesotherapy Applied?

  • Cellulite (most often)
  • Face, neck, and décolleté rejuvenation
  • Hair loss or lifeless hair
  • Tightening the skin that has lost elasticity (face, the region beneath the chin, neck, arms and legs)
  • Cracked skin
  • Body contouring
  • Wrinkles
  • Rejuvenation of the skin that has become dull, dreary or exposed to oxidant damage due to smoking, sunlight, or stress (face, neck, décolleté, back of the hand, and arms)

Which Materials are Used in the Mesotherapy?

  • The substances to be injected vary according to the mechanism of the problem. A number of active substances are used, such as:
  • For cellulite: Substances that increase blood flow, stimulate lymph flow, reduce edema, and burn fat
  • For hair loss: Substances that improve circulation, nourish hair follicles, and block the androgen
  • For facial rejuvenation: Vitamins, amino acids, minerals, hyaluronic acid, antioxidants, substances that stimulate and support collagen and elastic tissue

How Often and in How Many Sessions Should Mesotherapy Be Applied?

Mesotherapy is applied once a week or every two weeks (generally once a week for the body, every 7-10 days for the face, and every two weeks for the hair). Applying it more than once a week is not necessary in terms of the mechanism of action of mesotherapy. In addition, frequent application of mesotherapy increases the risk of side effects and is expensive for the patient. At least 3-4 sessions are needed to observe its effects. On average, 8-10 sessions for cellulite, 4-5 sessions for facial rejuvenation, and 8-12 sessions for hair loss are sufficient, but the number of sessions needed varies according to the person and the degree of the problem. As there are cases in which the effects are observed in 4 sessions, 10-15 and even sometimes 20 sessions may be needed for chronic, advanced cellulitis. Maintenance sessions are recommended after the patient achieves a satisfactory result. Maintenance therapies can continue for a period of time, first once in every fifteen days, then once a month, and once in every 2-3 months, depending on the problem.

Can Mesotherapy Be Combined with Other Cosmetic Applications?

Mesotherapy can be combined with Botox, filling, peeling, thread lift, skin rejuvenation with laser, but there should be a certain period between the procedures. This period is usually about a week.

Mesotherapy can also be applied before and after hair transplantation. It contributes to hair transplant treatment by increasing the circulation and nutrition in the treated area.

What Should Patients Consider Before a Mesotherapy Session?

The area to be treated should be clean to prevent the development of infection. For the same reason, you should wear clean clothes. There should be no make-up on your face. You should remove your make-up with alcohol or antiseptic so that there is no residue left. Also, you should not apply perfume or cream on the area to be treated, and if any, you should remove and clean them. You should not wear tight clothes such as skinny jeans, and also white or very light-colored clothes, because they might become stained. You should not take aspirin (even low dose), other painkillers, and vitamin E and not consume green tea in the last 3-4 days before the application, because they increase the possibility of bleeding.

What Should Patients Consider After a Mesotherapy Session?

You should not apply cosmetic products, do strenuous exercises, take a shower or bath, swim in the pool or sea, and sunbathe for 24 hours after mesotherapy. (Epithelial or antibiotic cream can be applied.)

You should care about the hygiene of the treated area for a couple of days.

If your sun-exposed areas are applied with mesotherapy, your doctor may recommend you sunscreen. In this case, you should put on sunscreen regularly.

You should avoid ionization for 48 hours.

What Should Patients Consider During the Process of Mesotherapy Treatment?

The best way to observe the effects of body mesotherapy is to wear a tight clothing, such as a tight dress or jumpsuit, once in every 4-5 sessions. Because mesotherapy is not primarily used for weight loss, but for tightening and shaping the body and removing the cellulite. For this reason, you can easily observe the effects that you cannot see on the weighting scale or with the tape measure when your clothes become loose-fitting for you. After 7-8 sessions, even if you might not lose weight, you will drop a size or two.

You should drink at least 2-3 liters of water a day during the process of body mesotherapy treatment. A healthy diet and physical exercises (such as walking, swimming, cycling) increase the effects. You should gain the habit of these to preserve the improvement that you achieved with mesotherapy for a longer time. You should care about the moisturization of your skin and protection of your skin from sunlight to experience long-lasting effects after the skin rejuvenation mesotherapy. You should not smoke or should minimize it.

During cellulite treatment, your doctor may recommend that you use orally administered circulatory medications, depending on the severity of the circulatory disorder you have. Also, smoking has an undeniable negative effect on the circulatory system.

You should take orally administered capsules or tablets, and use shampoos recommended by your doctor for your hair health during the hair mesotherapy process. They also increase the effects of the treatment. However, if you are using a hair nourishing product or taking medication that you used to take before, that your doctor has not recommended, please make sure to inform your doctor about them.

What are the Side Effects of Mesotherapy?

In mesotherapy, least side effects are aimed due to its technique, medications are given locally and in small amounts, and systemic side effects are minimal. The practitioner must be knowledgeable of skin anatomy and physiology, and of mesotherapy techniques. This plays an important role in preventing side effects.

The most common side effects are temporary redness, swelling and bruising at some injection points in the application area. Your doctor may recommend creams or tablets for faster healing of bruises. There may be sensitivity, pain and itching in the area for a day or two. Allergic reactions such as widespread itching and rash can be seen very rarely. If you prone to allergies, it would be helpful to inform your doctor in advance. Your doctor may take precautions such as applying a skin test or administering antihistamines before the session. The same is true for nickel allergy. Inform your doctor if you are allergic to imitation jewelry or metal because you may experience reactions to injection needles, such as skin rashes, even though you are not allergic to drugs.

You may experience a regional discomfort that lasts for a few hours after each session of mesotherapy in the period of adaptation to the treatment. An effective dialogue between the patient and the doctor makes it easier for the patient to tolerate this discomfort.

Who Can Have Mesotherapy Applied?

It can be applied to anyone between the ages of 18 and 75 with good general health. However, in body mesotherapy, we calculate the body mass index (BMI) of patients over a certain weight. We recommend our patients with a BMI value above 25 to follow a diet and do sports until their BMI is down to 25, then we take them to the mesotherapy program. (Most Turkish women are between the BMI range of 22-25 and suitable for mesotherapy.) When these conditions are provided, mesotherapy becomes more effective, and the need for recovery of sagging tissues due to weight loss is considered when determining the method to be used. In addition, it is more economical for the patient as the number of sessions that the patient needs will decrease after weight loss.

Who Cannot Have Mesotherapy Applied?

  • End-stage heart failure patients
  • Diabetics (especially those taking NPH)
  • Those with kidney failure
  • Patients with severe drug allergy (Aspirin, etc.)
  • Patients with severe metal allergy (Chrome, Nickel, etc.)
  • Cancer patients, patients receiving chemotherapy
  • Those who have had a heart attack before
  • Those with heart rhythm disorder
  • Those who have had a cerebrovascular event before (stroke, paralysis)
  • Hyperthyroidism patients
  • Those with bleeding disorders
  • Pregnant or breastfeeding women
  • Psoriasis patients (due to the possibility of injections irritating the skin and triggering new psoriasis lesions)
  • Those with active autoimmune diseases
  • Since bruising will be more in patients under anticoagulant treatment, a decision should be made with the doctor.
  • In addition, in the presence of a viral or bacterial infection in the area to be treated, mesotherapy is not applied until the infection is recovered.


Mesotherapy is a bit more vague than other fields of dermatology and cosmetology. We are not able to obtain crystal clear information about it, the publications are usually in French and Spanish. In fact, standards have not been set in terms of technique, dosage, efficacy and safety. There are certain formulas because it has been applied for decades. There are drugs that have been identified to be compatible with each other, but not the way it should be in science. It has been involved in science congresses in recent years. In this way, some scientists are trying to give it a place in the scientific arena. It has a status as I mentioned above. France has accepted it as a specialty in medicine, the USA has recognized it, Europe generally regards it as a part of medical studies, and the Ministry of Health accepts mesotherapy in our country.

The name mesotherapy is given because it is applied to the tissues that develop from the mesoderm layer of the embryo (the period after the fertilization and before the formation of organs in the womb). There is no layer called "mesoderm" in humans after birth, it is replaced by organs and tissues that develop from mesoderm.

The purpose of mesotherapy is to bring the treatment and the injection area closer to each other and to administer lower doses of the drug directly to the target. In fact, dermatologists have already used this technique for years. There are many diseases in which we inject one or a few drugs into the dermis depending on the type of disease: Psoriasis, lichen diseases, scars and keloids, acne, herpes, aphthae, warts, folliculitis, shingles, prurigo, etc.

Mesotherapy, which I have been applying since 2005, is a technique whose success I witnessed in cellulite, hair and other skin applications. It satisfies both the doctor and the patient. In mesotherapy, tissues are stimulated physically (with injections) and chemically (with drugs). Even if it is performed with a drugless and empty serum, it is possible to rejuvenate the tissue to some extent and stimulate healing with a good technique. This effect increases with drugs. We can observe the effects. However, the problem is that we cannot certainly know/predict what exactly we will get with which drug cocktail, dose and technique. Although I am skeptical of every unproven methods and applications, I hope that the standards of this method will be set over time and will be approved by evidence-based medicine.

Mesotherapy is one of the most permanent and effective weight loss applications known. The application can be with or without needles. It is applied to the middle layer of the skin. Mesotherapy treatment, which is used for regional thinning and in the treatment of cellulite, gives extremely successful results, especially in the abdomen, love handles, back, inner knee, arm, back of the leg, and hip regions. This treatment, which helps in weight loss by breaking down the fat molecules in the region, does not cause any pain in the areas where it is applied, and has no side effects. Apart from weight loss, mesotherapy is also used in anti-aging skin care, prevention of hair loss and treatment of joint disorders,

New Generation PRP

PRP "Growth Factors" treatment, which is widely used by many doctors and known by many patients, has recently started to be replaced by CGF-CD34 (Concentrated Growth Factor) treatment, which contains much more concentrated "Growth Factors and Stem Cells".

In PRP method, clotting cells in the blood, called thrombocytes or platelets, are used after being separated by special methods and activated (the growth factors in them are revealed). In CGF-CD34 treatment method, plasma fluid containing much more concentrated growth factors and hematopoietic (blood forming) stem cells (CD-34) is obtained with different activation processes.

In CGF-CD34 treatment, not only growth factors but also stem cells called CD34 are obtained. Therefore, it has been observed that CGF-CD34 treatment is a more effective treatment method than PRP.

How is CGF-CD34 Applied?

First, blood is drawn from the patient. Then, concentrated growth factors are obtained by special separation methods. The application area is cleaned with disinfectants and local anesthetic creams are applied.

Plasma fluid obtained can be applied

  • By direct injection,
  • By mesotherapy,
  • By micro-needling,
  • Inside a mask,
  • By spreading on the wounds.

The application takes 30-45 minutes in total including the preparation period.

CGF-CD34 Applications for Aesthetic Purposes

Our skin becomes aged along with the chronological aging. The aging process occurs quite slowly and chronically. Many genetic and environmental factors play a role in this process, and tissue repair mechanisms do not usually recognize this process. For this reason, in skin rejuvenation practices, we actually try to imitate what our body does while healing a wound. In CGF-CD34 application, we increase the healing capacity of the body by giving a high amount of repairing cells under the skin.

What Should Patients Consider After the CGF-CD34 Applications for Aesthetic Purposes?

Do not to wash or clean the application site, and put on make up for 4-6 hours.

Do not swim in the pool or sea for 12-24 hours after the application.

Do not use any anti-inflammatory medications after the injection as they will inactivate the natural healing process provided by CGF-CD34. However, if you feel persistent pain (that happens very rarely), you can take a paracetamol type painkiller or apply cold compress.

In addition, very hot baths, showers, Turkish baths, saunas and strenuous exercises are not recommended in the first 24-48 hours after the application.

What are the advantages of CGF-CD34 for Aesthetic Purposes?

  • No external chemicals or drugs are applied.
  • Plasma fluid a natural mixture obtained from the patient's own blood.
  • It does not cause allergic reactions or other side effects.
  • There is no risk of infectious diseases.
  • It is performed in a short period of time.
  • Its effects can be observed a short time after the application.
  • Its effects are permanent and long-lasting.
  • Application is easy and practical.
  • It does not require hospital or operating room conditions.
  • It has similar effects to filling and mesotherapy and can be combined with these methods.

Cellulite Treatment

Hydrolipodystrophy, cellulite in colloquial language, occurs when subcutaneous adipose tissues are herniated within connective tissues due to many reasons such as, frequent weight gain and loss, malnutrition, and hormonal disorders. It appears like orange peel. Most women face this problem. Most commonly affected areas are upper thighs, inner parts of the knees and ankles, buttocks, back of the calves, upper legs, and upper arms. There are many factors that lead to cellulite. However, the most prominent ones are genetic predisposition, effects of hormones, circulatory disorder, unhealthy dietary habits, and sedentary lifestyle.

In cellulite treatment, application of creams, massage with these creams, and subcutaneous injections are very effective. Patients can achieve very good results with cupping massage, subcutaneous injections, and acupuncture for cracks and/or cellulite that occur especially during the weight loss process.

Regional Slimming

Many people follow a diet but never be able to burn fat in some areas. It is difficult to burn fat that has been in the hip and belly areas for a long time, even with sports and diet. People also suffer from sagging after losing weight with acupuncture treatments. At some point, people stop losing weight. Then, they quit their diet due to disappointment they feel and the belief that they will never lose weight again. For this reason, they put on weight rapidly. It is very effective to perform regional slimming applications at these stages. There are many cosmetic products and methods used in regional slimming. While some of them are effective, some of them are not.

Studies have shown that the most effective regional slimming method is to make the person's own body to burn these fats. So, how is this possible? With electrolipolysis, an acupuncture method. In the acupuncture method, the ability of the body to treat itself is assisted by the needles that are inserted into the energy pathways of the body. Electrolipolysis also breaks down the fibers between the solidified adipose tissue with a similar effect and enables the body to break down these fats on its own.

Treatment of Cracks and Scars

Cracks (striae in medical language), which most of us suffer from, occur as a result of the changes in the structure of elastin and collagen fibers in the middle layer of the skin, called dermis, due to various factors. While it is possible to remove it with simple methods in the early stages, it requires scar treatment in advanced stages.

Cracks usually occur in the most stretched areas of the skin in cases of excessive weight gain and loss, pregnancy, use of some medications and after hormone treatments. It starts off with small lines that does not look nice. They are generally sunken scars called atrophic scars. Their colors are close to purple and red when they are newly formed. As they age, their colors lighten and become gray-like.

The most commonly affected areas are the abdomen, breasts, waist, upper arms, inner parts of the legs and knees. The fact that skin cracks are observed mostly in women suggests that hormonal conditions are also among the influencing factors. Cracks are observed especially in 80% of women in the postpartum period.

When we examine the cracked tissue, we observe that the tissue components that hold the tissues tight and refreshed, called connective tissue components, have decreased, and lost their flexible structure. In order to eliminate this aging and loosening, it is necessary to rebuild the connective tissue components in the tissue. In this way, the skin becomes tighter and more refreshed, and the cracks are reduced. Therefore, the cracks should be treated immediately after they form. Cracks can be treated quite successfully especially within the first 6-12 months. Chemical peeling applications, dermarolling applications, glycolic acid, glutathione, hyaluronic acid, retinoic acid, multivitamin and multimineral solutions and mesotherapy treatments may be sufficient for cracks that have not progressed to scar formation stage. However, the combined use of CGF (concentrated growth factor), Dermapen and mesotherapy agents provides successful results in the treatment of advanced, deepened, scar-like cracks.

Hair Loss

Hair has been very important to women and men for centuries. Especially in ancient times, it became a symbol of sovereignty and showed the power of women. In many civilizations, a number of icons and sculptures related to hair have been made. Since hair is that important, loss of hair is also very important.

When does hair loss become serious? We can understand this with a very simple test. Pull a strand of hair (containing about 20-30 hairs) from any area of your hair quickly. If you have 5-6 or more hair left in your hands, you should definitely go to a specialist and take precautions.

Studies have shown that 100 strands of hair loss per day is normal. Hair loss can be caused by medical problems as well as environmental factors. Causes such as improper work of the thyroid gland, genetic predisposition (especially in men), anemia problems, scalp problems, iron deficiency, hormone irregularity are among the medical problems. Apart from this, problems such as insufficient hair care and unbalanced nutrition can also cause hair loss. Therefore, the cause of hair loss should be determined first.

If no medical problem is detected, environmental factors should be questioned. Smoking and alcohol drinking habits, diet, stress, hair care, the content and change of hair cleaning products used are important factors.

Hair loss is significantly prevented if it is intervened at the early stages. Solving the underlying medical problem and applying treatments on the scalp and hair solve the problem radically.

However, if the patient has a genetic predisposition and suffers intense hair loss (if the treatment of the underlying medical problem will take time), CGF (concentrated growth factor) application is applied to prevent hair loss quickly. The results are very effective with care creams and hair root applications to be used after this application, whose effect you can observe very quickly and clearly.

Skin Rejuvenation

Aging is the gradual decrease in the normal physical and mental functions of a person. The place where this affects our external appearance is our skin. Aging signs that appear on our skin always bothers us because it proves us and the world outside that we are aging. Although our soul is young and there are many things we plan to do, those aging signs on our skin upset us. So, what are the factors that cause aging in our skin?

Time: This is a factor that we cannot change, and we continue to age every second, every moment.

Oxidants in the skin and body: Emerging as a result of metabolism, these factors are the main causes of aging and cancer.

Sun: You should be protected from sunlight between 10:00 am and 3:00 pm. You should reapply your sunscreen in every two hours.

Smoking: It accelerates aging by affecting many factors.

Not drinking enough water: Adequate daily water intake is 35-45 ml/kg. If you drink less than this, your immune system become suppressed and regeneration decreases. Tea, juices, and coffee never replace water.

Sugar: It weakens the immune system. It causes sagging of the skin and aging by damaging to cells. Bakery products also cause these.

Alcohol: It weakens the liver and reduces the related skin regeneration factors. The sugar included in alcohol also causes many factors.

Caffeine: It causes moisture loss as it is diuretic. This increases wrinkle formation.

Stress: It has negative effects on the skin by affecting the immune system.

Insomnia: Adequate and uninterrupted sleep is very important for melatonin secretion.

Malnutrition: Nutrition that increases free oxygen radicals disrupts the skin.

It is very important to change your dietary habits and to use methods that will contribute to the rejuvenation of the skin in order to prevent skin aging and remove the signs of aging. Is it correct to inject or apply external substances to our skin? Instead, it is much healthier to achieve skin rejuvenation by using your body's own self-repair ability. It is very effective to insert needles only in certain areas and to release subcutaneous rejuvenation molecules. The most effective methods to rejuvenate your skin, remove wrinkles and create a smooth skin are:

Cosmetic Acupuncture

Performing applications by penetrating into the skin (with the depth of 0.4 to 0.5 cm)

Application of CGF (concentrated growth factors) into the skin

Fibroblast Application

It is the use of skin fibroblast cells of the person in order to correct wrinkles that develop in the facial area. This is the most popular anti-aging application of recent years. In this method, a piece of skin, usually the size of a rice grain, taken from behind the ear, is reproduced millions of times in the laboratory and they are injected into the skin line of wrinkles with a fine-tipped needle.

Quality and harmlessness tests (sterility, endotoxin, mycoplasma) are performed to show that your cells have the required properties for this application, which is performed 3 times with 3-4 weeks intervals. Then, the cells are delivered to the practitioner immediately or, if desired, frozen and stored to be applied at any time. Atibank, an Atigen-cell organization, allows you to use your younger cells in the following years by keeping your cells safe for this purpose for years.

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